Margaret Frame graduated with a first class honours BSc in Biochemistry, followed by a PhD from the Medical Faculty, both at the University of Glasgow. She worked for a brief period in industry, and then joined the MRC Virology Unit in Glasgow as a post-doctoral scientist until 1987. After time off for family, she returned to work at the Beatson Institute for Cancer Research in 1991, first as a post-doc and then subsequently as a group leader. In 1995, she was jointly appointed as Professor of Cancer Research in the Faculty of Biological Sciences at the University of Glasgow and the Beatson Institute, where she became Deputy Director in 2002. She was awarded the Tenovus Medal in 1999 for her work on Src family kinases, was elected a Fellow of the Royal Society of Edinburgh in 2002, an EMBO Member in 2008 and a Fellow of the Academy of Medical Sciences in 2010.
Margaret Frame’s long-held research interests are in cancer invasion and metastasis, and the role of tyrosine kinases in controlling tumour cell spread. She has had several CR-UK funded programs of research to work on understanding cancer invasion and metastasis, the key hallmarks of malignancy, and was recently awarded an ERC Advanced Investigator grant to build a novel cancer discovery platform. Her major goal is to work with clinicians treating cancers of unmet need, to determine whether, and if so how, targeting the invasive and metastatic processes may be therapeutically beneficial, and may be monitored in the preclinical and clinical settings by novel imaging techniques.
Margaret Frame joined the new MRC-University of Edinburgh Institute of Genetics and Molecular Medicine in October 2007. She co-directs the Edinburgh Cancer Research Centre in Edinburgh University’s College of Medicine and Veterinary Medicine, with the role of Science Director in the recently established Cancer Research UK Centre (from January 2010). The vision of the Edinburgh Cancer Research Centre she directs is to develop novel and emerging technologies for the development of innovative cancer discovery and translational science. Together with close colleagues, she has recently formed the Edinburgh Cancer Discovery Unit (http://www.ecrc.ed.ac.uk/edinburgh-cancer-discovery-unit/edinburgh-cancer-discovery-unit), increasingly funding via several pharmaceutical company alliances, Edinburgh BioQuarter and CR-UK Drug Discovery Office; the vision is to generate evidence-led tests for cancer therapeutics and combinations that will predict clinical efficacy.
Margaret Frame also recently became Director of Research in the College of Medicine and Veterinary Medicine at the University of Edinburgh. She is a former Chair (or member) of several funding panels; Association of International Cancer Research, NCI Animal Models of Cancer, Welcome Trust Genes, Molecules and Cells, CR-UK Science Project and Program Funding, and is the current Chair of Cancer Research UK's Career Development Panel and Training Board, and serves on several Advisory Boards in the UK and across Europe, including Department of BioMedizin, University of Basel and the Marseilles Institute of Biology.